Istradefylline 40 mg/working day elevated peak degrees and AUC of CYP3A4 substrates in medical trials. This impact wasn't noticed with istradefylline 20 mg/working day. Take into consideration dose reduction of delicate CYP3A4 substrates.darifenacin will enhance the stage or impact of triazolam by impacting hepatic/intestinal enzyme CYP3A4 metaboli